Kisaragi was hired by Kurama despite the doubts of many other people, and at times, despite doubts held by other staff about Kurama. It's known that Kurama kept a picture of her next to the ones of his late wife Hiromi and Nana, whom he considered like his own daughter. The affection between the two seemed familial and genuine, much like many relationships between office ladies and their bosses. It was Kisaragi who informed Kurama that his wife Hiromi, pregnant with their daughter Mariko, had been taken to the hospital with birth complications.
During Lucy's escape at the start of the series, Kisaragi literally stumbled into a firefight between Lucy and the facility's guards, and was promptly killed. Kisaragi is later seen in flashbacks set prior to the start of the series. Her death is one of many things that drive the bitter enmity between Lucy and Kurama.
Manga vs. Anime
In the manga, Lucy takes Kisaragi hostage and plans to use her to open the escape door to the facility. Kurama explains to Kisaragi that he cannot allow Lucy to escape, and must fire through her. Kisaragi accepts this with grace, happy to help her boss despite being terrified of dying, but Lucy quickly decapitates her and uses her body as a shield against the guards' gunfire, taunting Kurama that her death was now meaningless. Kurama, enraged by Lucy's act, vows to take revenge upon her.
In the anime, Kisaragi's death is not as dramatic, yet still very gruesome. Lucy immediately decapitates her and uses her body as an unnecessary bullet shield when she realizes Kurama, whom she hates, is fond of her. Kisaragi is among the most notable casualties of the memorably violent first seven minutes of the anime's first episode, and like many others, her death is shown in vivid detail.
In the English dub, Kisaragi's name is mispronounced as "Kisagari" by another secretary when she first appears.
The design for Kisaragi's look and character may have been inspired by Love Hina's Mutsumi Otohime, who was also known for being a sweet airhead as well as more than a bit clumsy. Both characters are also depicted with long hair bangs, and Mutsumi was at least a student at Tokyo University, and was doing graduate work as the series ended.