|Age:||Around 30 years old|
| Character Information
|First seen:||Manga: Chapter 2|
Anime: Episode 4
|Last seen:||Manga: Chapter 63|
Anime: Episode 13
|Voice actor (Japanese):||Naoki Kinoshita|
|Voice actor (English):||Rick Piersall|
Isobe was Kurama´s personal assistant. His biography and personality are completely different between the manga and the anime, with him playing a much more complex role in the manga. While it is never stated directly, it seems likely he gained his position when Kurama's original assistant Oomori left the Diclonius Research Institute after the euthanizing of his infant daughter, a Diclonius.
|“||Are you really sure you're willing to set free a monster even worse than Lucy?||”|
Working as a personal assistant to Kurama, this character is rarely addressed by name, but appears in and effects events in many chapters of the manga series, nearly from the start. Along with Shirakawa, his most prominent appearance occurs when he is given charge over Mariko's mission to hunt down Lucy, when Kurama abruptly leaves and Saito is savagely killed by Mariko. After Saito's death, Isobe develops a low opinion of her, feeling that she manipulated Mariko's emotions regarding her parents' love for her. He is also present when Mariko and Nana argue about Kurama without realizing each is talking about the same man. A morally-conflicted man, he feels that implanting the bombs in Mariko's body is inexcusable, but stands ready with the remote control to either temporarily delay the bombs' detonation or selectively blow them up at will. Slicing away the arm that held the remote, Mariko emotionally manipulates him into giving her the anti-detonation codes, and then taunts him before finally beheading him. It can be speculated that knowledge of the fate of his predecessor Oomori and sympathy for his plight made him more open to Mariko's trickery.
|“||Shirakawa! Don't stray from our orders! Our mission is to kill Number Seven.||”|
–Isobe, decidedly colder in the twelfth anime episode
In the anime, Isobe is a colder and less complex character, who seems to have no problem using or controlling Mariko (though he is shocked by the method chosen to control her), or even with firing on Shirakawa when she urges restraint at one point, indiscriminately attacking her, Nana and Kouta. In the end, he watches as Mariko and Kurama die together, and is prepared to execute Nana despite knowing how much his late boss loved her. He is killed by Lucy before he can do this.